A drug dosage regimen providing desired drug dosage per days was developed for contraception based on natural estrogens. S. Fricke, H.A. Hoffmann, C. Moore, M. Oettel, M. Ostertag were members of the inventor group. Because of the alphabetic order, the group was mentioned as „the Dittgen group„, and the multi-phasic dosing pattern was named “the Dittgen Regimen„. A regimen providing desired drug dosage per hours was created as capsules with pulsatile release of melatonin. The regimen was verified in a pilot study in humans. Beside of the inventors mentioned above, the following authors were involved: C. Bartsch, H. Breitbarth, J.-D. Fauteck, K. Farker, A. Hoffmann, U. Mellinger, A. Lerchl, T.H. Lippert, H. Osterwald, H. Schmidt, U. Schmidt, C. Timpe, H. Zimmermann.
